It is estimated that 300,000 children 0–14 years of age are diagnosed with cancer worldwide each year. While the absolute risk of cancer in children is low, it is the leading cause of death due to disease in children in high‐income countries. In spite of this, the etiologies of pediatric cancer are largely unknown. Environmental exposures have long been thought to play an etiologic role. However, to date, there are few well‐established environmental risk factors for pediatric malignancies, likely due to (...) technical barriers in collecting biological samples prospectively in pediatric populations for direct measurements. In this review, we propose the use of novel or underutilized biospecimens (dried blood spots and teeth) and molecular approaches for exposure assessment (epigenetics, metabolomics, and somatic mutational profiles). Future epidemiologic studies of pediatric cancer should incorporate novel exposure assessment methodologies, data on molecular features of tumors, and a more complete assessment of gene‐environment interactions. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Résumé Après l’enthousiasme soulevé par le début des années 1990, les peuples autochtones de Sibérie ont dû relever de nombreux défis. Dans le nord-ouest sibérien, au-delà des associations qui militent pour la reconnaissance et les droits autochtones, des expériences individuelles ont vu le jour, qui chacune à leur façon, puisent dans la culture traditionnelle pour s’adapter au cadre complexe de la Fédération de Russie.

Abstract Scientific, technological, ethical, and religious issues confronting the human prospect are emerging as we encounter the inevitable shift from fossil to renewable fuels. In particular, we are entering a period of monumental transition with respect to both the forms and use of energy. As for any technological transition of this magnitude, ultimate success will require good ethics and religion, as well as good science and technology. Economic and political issues associated with energy conservation and renewable energies are arising in (...) the context of climate change, sustainability, and human purpose. Specifically, we must consider (1) ethical and religious perspectives which might guide future energy choices and (2) energy choices which, in turn, might challenge ethical and religious perspectives. In this paper, I set the stage for subsequent articles by introducing thermodynamic and theological considerations relevant to our energy future. Scientific and technological aspects are covered within the context of the first and second laws of thermodynamics. Ethical and religious aspects are covered within the context of basic philosophical and theological motifs within our secular culture. My intention is to provide the necessary background, motivation, and perspectives for a fuller discussion of pertinent issues in the remainder of the conference papers. (shrink)

Ce texte de Normand Baillargeon part de son expérience de philosophe ayant œuvré dans un département universitaire de sciences de l’éducation au Québec durant plus de 25 ans. Cette expérience parait étayer deux idées que qui méritent d’être portées à l’attention de quiconque se préoccupe de l’état de notre système d’éducation et des débats qu’il suscite. La première de ces idées est que la philosophie de l’éducation est une discipline trop profondément négligée, tant par les philosophes que par les (...) gens œuvrant en sciences de l’éducation et par les décideurs des politiques publiques. La deuxième est que cette négligence peut avoir, et a bien souvent, des conséquences déplorables, voire dramatiques. En espérant avoir à tout le moins convaincu les lecteurs de la plausibilité de ces deux idées, ce texte se termine par la suggestion de quelques pistes d’action susceptibles de corriger cet état de fait. (shrink)

Information can be public among a group. Whether or not information is public matters, for example, for accounts of interdependent rational choice, of communication, and of joint intention. A standard analysis of public information identifies it with (some variant of) common belief. The latter notion is stipulatively defined as an infinite conjunction: for p to be commonly believed is for it to believed by all members of a group, for all members to believe that all members believe it, and so (...) forth. This analysis is often presupposed without much argument in philosophy. Theoretical entrenchment or intuitions about cases might give some traction on the question, but give little insight about why the identification holds, if it does. The strategy of this paper is to characterize a practical-normative role for information being public, and show that the only things that play that role are (variants of) common belief as stipulatively characterized. In more detail: a functional role for “taking a proposition for granted” in non-isolated decision making is characterized. I then present some minimal conditions under which such an attitude is correctly held. The key assumption links this attitude to beliefs about what is public. From minimal a priori principles, we can argue that a proposition being public among a group entails common commitment to believe among that group. Later sections explore partial converses to this result, the factivity of publicity and publicity from the perspective of outsiders to the group, and objections to the aprioricity of the result deriving from a posteriori existential presuppositions. (shrink)

Should we regard Jennifer Lackey’s ‘Creationist Teacher’ as understanding evolution, even though she does not, given her religious convictions, believe its central claims? We think this question raises a range of important and unexplored questions about the relationship between understanding, factivity and belief. Our aim will be to diagnose this case in a principled way, and in doing so, to make some progress toward appreciating what objectual understanding—i.e., understanding a subject matter or body of information—demands of us. Here is the (...) plan. After some ground clearing in §1, §2 outlines and motivates a plausible working model—moderate factivity—for characterising the sense in which objectual understanding should be regarded as factive. §3 shows how the datum that we can understand false theories can, despite initial suggestions to the contrary, be assimilated straightforwardly within the moderate factivity model. §4 highlights how the inverse kind of case to that explored in §3—viz., a variant of Lackey’s creationist teacher case—poses special problems for moderate factivity. With reference to recent work on moral understanding by Hills, §5 proposes a solution to the problem, and §6 attempts to diagnose why it is that we might originally have been led to draw the wrong conclusion. (shrink)

Ce texte est le fruit d’une collaboration entre un astrophysicien, Jean-René Roy, et un philosophe de l’éducation, Normand Baillargeon. Ils ont en commun d’avoir été marqués par la fréquentation des oeuvres de Mario Bunge, auxquelles ils attachent un grand prix, sur un plan personnel, d’abord, mais aussi, et c’est ce qu’ils veulent rappeler dans ces pages : parce qu’ils estiment que les oeuvres de Bunge contribuent de manière extrêmement forte et positive à rendre plus salubre la vie de l’esprit, (...) en enrichissant notre intellect et en luttant contre diverses formes troublantes d’obscurantisme qui y sévissent parfois, notamment dans les domaines familiers aux deux auteurs. (shrink)

The ante rem structuralist holds that places in ante rem structures are objects with determinate identity conditions, but he cannot justify this view by providing places with criteria of identity. The latest response to this problem holds that no criteria of identity are required because mathematical practice presupposes a primitive identity relation. This paper criticizes this appeal to mathematical practice. Ante rem structuralism interprets mathematics within the theory of universals, holding that mathematical objects are places in universals. The identity problem (...) should be read as challenging this claim about universals. However, what mathematical practice presupposes is only relevant to what is true according to the theory of universals, if one takes it for granted such a theory offers the best interpretation of mathematics. In the current context, taking this for granted begs the question. Therefore, the appeal to mathematical practice in response to the identity problem is illegitimate. (shrink)

Revonsuo proposed an intriguing and detailed evolutionary theory of dreams which stipulates that the biological function of dreaming is to simulate threatening events and to rehearse threat avoidance behaviors. The goal of the present study was to test this theory using a sample of 212 recurrent dreams that was scored using a slightly expanded version of the DreamThreat rating scale. Six of the eight hypotheses tested were supported. Among the positive findings, 66% of the recurrent dream reports contained one or (...) more threats, the threats tended to be dangerous and aimed at the dreamer, and when facing a threat, the dreamer tended to take defensive or evasive actions that were possible and reasonable. However, less than 15% of the recurrent dreams depicted realistic and probable situations critical for one’s physical survival or reproductive success and the dreamer rarely succeeded in fleeing the threat despite important and appropriate efforts. The findings thus provide mixed support for the threat simulation theory. (shrink)

Normand Baillargeon, dans ces Légendes pédagogiques, se veut très mordant, virulent parfois, mais toujours juste et honnete dans ce qui se veut une mise en perspective de nos idées reçues sur l'éducation.--[Memento].

Dans cet article, nous cherchons à penser les enjeux philosophiques et politiques de l’application des méthodes interprétatives en histoire de la philosophie politique. À partir d’une étude de l’interprétation de Machiavel développée par Quentin Skinner, nous interrogeons la relation entre l’exposition théorique de sa méthodologie et son application effective à la pensée machiavélienne. Dans un premier temps, nous exposons les fondements du contextualisme skinnérien, en insistant d’une part sur sa critique des méthodes orthodoxes en histoire des idées, et d’autre part, (...) sur sa conception de l’intentionnalité d’un auteur du passé et sur la relation étroite entre théorie politique et vie politique qu’elle présuppose. Dans un second temps, nous analysons la mise en œuvre de cette méthode à partir du cas Machiavel, en illustrant les résultats féconds ainsi que les limites d’une telle théorie interprétative. Nous terminons par une analyse critique du projet politique qui sous-tend l’application de cette herméneutique. La thèse défendue est que la relation entre la dimension méthodologique et la dimension proprement politique de l’entreprise skinnérienne est marquée par une certaine tension. D’un côté, Skinner affirme que l’historien ne peut, et ne doit, retirer de leçons intemporelles de l’étude des auteurs du passé; la notion même de continuité entre les époques – l’idée d’une « grande Tradition » – serait un leurre. De l’autre, il critique la conception négative de la liberté mise de l’avant par des auteurs tels que John Rawls ou Isaiah Berlin, et propose une vision renouvelée du républicanisme qui puiserait à la source machiavélienne et permettrait de réconcilier liberté individuelle et participation citoyenne. En explorant tour à tour ces deux volets et l’articulation parfois problématique entre les deux, nous interrogeons la nature de cette équivoque entre les visées méthodologiques de Skinner en tant qu’historien des idées et son propos en tant que théoricien politique. (shrink)

Avicenna (d. 1037) bequeathed the Arabic philosophical tradition with an aporia : self-knowledge is conceived, at times, in terms of intellection, at other times, in terms of apperception. In his Book of Discussions and Book of Notes, Avicenna has lengthy discussions on apperception, defined as a direct ontological mode of knowledge. Heir to this tradition, Shihāb al-Dīn al-Suhrawardī (d. 1191) moved away from the first conception of self-knowledge as intellection to adopt the second conception of an apperception of the self (...) as a direct, intuitive and "presential (hcombining dot belowudcombining dot belowūrī)" perception, and which he defended with four types of arguments. (shrink)

De manière remarquablement constante, la question de l'éducation a été une préoccupation majeure du mouvement anarchiste tout au long de son histoire. Malheureusement, cet héritage demeure en général méconnu, si ce n'est ignoré. Une des ambitions de cette anthologie, qui réunit des textes importants de penseurs et de praticiens anarchistes d'horizons divers, est précisément de nous permettre de redécouvrir la riche tradition dans le domaine de l'éducation de ce courant politico-philosophique. Qu'est-ce que l'éducation? Sur quels plans et pour quelles raisons (...) l'éducation, telle que généralement pratiquée, est-elle déficiente? Comment devrait-on s'y prendre pour former des êtres libres? À ces questions et à de nombreuses autres semblables, des théoriciens ont tenté de répondre, tandis que des praticiens anarchistes se sont efforcés de mettre en oeuvre leur idéal d'une éducation réellement émancipatrice. La présente anthologie, qui comprend deux tomes, réunit les principaux écrits consacrés à l'éducation de ces théoriciens et praticiens anarchistes, des écrits trop peu connus et souvent difficilement accessibles. On retrouve dans ce premier tome, qui couvre les années 1793 à 1918, des textes de Michel Bakounine, Sébastien Faure, Francesco Ferrer, William Godwin, Pierre Kropotkine, Fernand Pelloutier, Pierre-Joseph Proudhon, Paul Robin et Max Stirner. Ils mettent en lumière une riche et toujours inspirante tradition de pensée, de militantisme et de réalisations concrètes. (shrink)

Le present travail propose une analyse philosophique de l'esthetique d'Andre Breton. ;Meme si, en raison de l'importance du surrealisme au XXeme Siecle, cette doctrine semble bien incontournable pour quiconque s'interesse a l'esthetique, elle n'a guere fait, a ce jour, l'objet d'une veritable reflexion philosophique. Notre travail repose donc d'abord sur l'hypothese que l'oeuvre de Breton presente un interet du point de vue philosophique, hypothese qui est etablie en introduction. Faisant ensuite etat des difficultes que rencontre tout examen philosophique du surrealisme, (...) nous precisons le sujet que nous avons retenu compte tenu de ces difficultes: il s'agit de la question de l'art comme manifestation sociale et donc des deux problemes suivants: celui de l'autonomie de l'art, d'une part; celui de l'engagement de l'artiste, d'autre part. ;La suite de notre travail est consacree a une lecture interne des textes de Breton qui permet de cerner le point de vue surrealiste sur ces deux problemes, cette demarche etant menee selon l'approche diachronique que nous avons retenue. Nous sommes parvenus a etablir que Breton croit d'une part en l'autonomie du probleme artistique et d'autre part que l'art authentique est, par la seule vertu de cette authenticite, revolutionnaire et engage. Les corollaires de ces idees sont qu'aucun artiste ne saurait, au risque de nier la signification et la portee de sa demarche propre, ignorer, dans sa discipline, l'etat donne du probleme artistique; que rien ni personne ne saurait dicter a l'art la nature ou la fonction de sa demarche; enfin, que c'est l'art authentique qui fait l'art revolutionnaire et non pas l'art revolutionnaire qui fait l'art authentique. ;Au total, l'oeuvre de Breton promeut une conception revolutionnaire de l'art dont nous avons cherche a degager l'essentiel du point de vue philosophique--option metaphysique moniste d'un univers cryptogrammatique, surrationalisme, surdetermination de l'esthetique par l'ethique--et qui font de son oeuvre une des plus passionnees et des plus convaincantes defense et illustration de l'art au XXeme Siecle. (shrink)

La confrontation que nous chercherons à faire ici porte sur deux entreprises contemporaines que nous conviendrons de placer dans le mouvement structuraliste, celle de Foucault dans les Mots et les Choses, et celle des empiristes logiques dans leurs multiples travaux d'analyse du langage scientifique.

L’impact social de la science et de la technologie se manifeste par une série de relations que le présent modèle va découper sur des boucles de rétroaction. L’activité techno-scientifique des humains crée des perturbations dans le réseau des relations interindividuelles et sociales ainsi que dans l’environnement physique ; en retour, les environnements sociaux et physiques ainsi modifiés exercent des déterminations qui conditionnent et affectent la poursuite des activités initiales. De plus, à toutes les étapes de ces boucles de rétroaction jouent (...) des relations, en boucles également, par lesquelles certaines actions individuelles produisent un effet social et des états de choses collectifs produisent des effets sur les comportements individuels.Science and technology affect social life through numerous relations and the present model undertakes to picture the main ones as specific portions of feedback cycles. By its very creativity in science and technology man induces changes in the network of interindividual and social relations, and drastically modifies the physical environment ; those social and physical changes, in turn, serve as conditions and causes for retroactive changes in the human scientific and technological behavior. Furthermore, the model introduces the concept of " amplification socioficatrice " in order to highlight those additional relations through which certain individual actions or reactions come to have a social effect and existence in the midst of the generalized loop relations obtaining between individual and society. (shrink)

ABSTRACTAnte rem structuralists claim that mathematical objects are places in ante rem structural universals. They also hold that the places in these structural universals instantiate themselves. This paper is an investigation of this self-instantiation thesis. I begin by pointing out that this thesis is of central importance: unless the places of a mathematical structure, such as the places of the natural number structure, themselves instantiate the structure, they cannot have any arithmetical properties. But if places do not have arithmetical properties, (...) then they cannot be the natural numbers. The self-instantiation thesis turns out to be crucial for the identification of mathematical objects with places in structures. Unfortunately, we have no reason to believe that the self-instantiation thesis is true. (shrink)

This paper addresses the question of the existence and transmission of Buddhism in British culture in the 1930s. It argues that Buddhism found channels of transmission through popular culture, such as James Hilton’s 1933 novel Lost Horizon. Lost Horizon can be understood historically in relation to current Western ideas about Buddhism, and in response to the sense of historical crisis of Western modernity. This paper also shows that elements of a more genuine Buddhism are extracted from orientalist materials and deployed (...) by Hilton in ways that make the novel a carrier of quasi-Buddhist ideas. (shrink)

RésuméDans cet article, nous examinons le projet d'une critique de la raison historique mené par Wilhelm Dilthey et l'accusation d'historicisme portée contre lui par Heinrich Rickert. En comparant leurs tentatives respectives d'offrir un fondement philosophique aux sciences humaines, nous montrons que Dilthey et Rickert, en dépit de leurs divergences, convergent vers une réinterprétation productive de l'historicisme et conduisent à une reconfiguration de la relation entre philosophie et histoire. Cet article analyse trois implications théoriques et pratiques de l'historicisme : la mise (...) en valeur du particulier, le caractère historiquement situé du sujet connaissant et la primauté de la conscience historique. (shrink)

Protagoras, of all the ancient philosophers, has perhaps attracted the most interest in modern times. His saying ‘Man is the measure of all things’ caused Schiller to adopt him as the patron of the Oxford pragmatists, and has generally earned him the title of the first humanist. Yet the exact delineation of his philosophcal position remains a baffling task. Neumann, writing on Die Problematik des ‘Homo-mensura’ Satzes in 1938,2 concludes that no certainty whatever can be reached on the meaning of (...) the dictum, since ‘man’, ‘measure’, and ‘things’ are all ambiguous, nor can we tell which of the three is the predicate. The time is past when it was believed that a man's philosophy could be understood apart from the events of his life and the circumstances of his age: yet in the case of Protagoras the historical method of approach has hardly been attempted, although the impact of environment was perhaps more decisive in the formation of philosophical concepts in the Greek world than anywhere else. The reality about which the Greek philosopher spoke had three aspects: it was either the one universe of physics, or the political unity, or God. For example, the book of Heracleitus Περ φσεως was divided into three chapters or logoi, About the Whole, a political, and a theological. Neither physics nor theology supplies from its own subject-matter the form in which this reality was described. (shrink)